王璋倩 副教授
女,致公党党员,研究生学历,农学博士,药学博士后。博士阶段主要从事天然产物研发,微生物资源利用等研究工作,在Angewandte Chemie International Edition,Journal of the American Chemica Society,Pest Management Science等国际权威SCI期刊上发表论文20余篇,申请授权中国发明专利5项,主持起草的《微生物源纳米硒植物营养液》作为国家团体标准获批发布。主持承担国家自然科学基金、湖北省自然科学基金面上项目、中国博士后科学基金(一等资助)等纵横向科研项目10余项。入选湖北省省级人才计划、湖北省“三区人才”、湖北省第三批中小微企业“科技副总”、武汉市科技特派员。
联系方式:wzqsnu❀whpu.edu.cn
研究领域
天然产物的生物合成(微生物体内醌类及萜类合成基因的挖掘)
硒在微生物中的吸收转运及代谢工程改造
中药材天然产物活性成分研究及药食同源产品开发
中药材生产质量管理规范(GAP)
教育背景
2016.02-2018.11 博士后 武汉大学药学院 邓子新院士团队 刘天罡教授课题组
2008.09-2015.08 博士 韩国国立首尔大学 农业与生命科学学院 农业生命工学 导师:Ahn Young Joon 教授(韩国翰林院 院士)
2010.11-2011.03 访学 暨南大 药学院 中药及天然药物研究所 姚新生院士团队
2003.09-2008.03 学士 韩国国立首尔大学 农业与生命科学学院 应用生物化学
代表论文
1. Duan YH., Fang F, Mu X, Wang H, Shen Z, Deng Z,Wang ZQ*,Liu R*:Exploration of Streptomyces fradiae J1–021 as a Potential Host for the Heterologous Production of Spinosad. 2024. Journal of Agricultural and Food Chemistry, 72(16), 8983-8992.https://10.1016/j.gr.2024.01.007(影响因子:5.895 一区)
2. Wang YD, Yu YH, Duan YH, Wang Q, Cong X, He Y, Gao C, Hafeez M, Jan S, Rasheed SM, Cheng SY, Wang ZQ*: Enhancing the Activity of Carboxymethyl Cellulase Enzyme Using Highly Stable Selenium Nanoparticles Biosynthesized by Bacillus paralicheniformis Y4. Molecules 2022, 27(14).https://doi.org/10.3390/molecules27144585 (影响因子:4.927 二区)
3. Wang ZQ,Deng JY, U Muhammad, Anwar Naureen, Wang YD,Dong XX, Xu H, He Y,Gao Chao: RHPS4 shifted the conformation ensemble equilibrium of Tel24 by preferentially stabilizing the (3 + 1) hybrid-2 conformation. RSC Advances, 2022, 12, 26011. https://doi.org/10.1039/d2ra03959a (影响因子:4.036 三区)
4. Hafeez M, Ullah F, Khan MM, Wang ZQ, Gul H, Li XW, Huang J, Siddiqui JA, Qasim M, Wang RL, Imran M, Assiri MA, Rehman M, Fahad S, Lu YB: Comparative low lethal effects of three insecticides on demographical traits and enzyme activity of the Spodoptera exigua (Hubner). Environmental Science and Pollution Research 2022, 29(40):60198-60211.https://doi.org/10.1007/s11356-022-20182-5
5. Siemon T, Wang ZQ, Bian GK, Seitz T, Ye ZL, Lu Y, Cheng S, Ding YK, Huang YL, Deng ZX, Liu TG, Christmann M: Semisynthesis of Plant-Derived Englerin A Enabled by Microbe Engineering of Guaia-6,10(14)-diene as Building Block. Journal of the American Chemical Society 2020, 142(6):2760-27650. https://doi.org/10.1021/jacs.9b12940
6. Zhang XM, Wang ZQ, Jan S, Yang Q, Wang M: Expression and functional analysis of the lysine decarboxylase and copper amine oxidase genes from the endophytic fungus Colletotrichum gloeosporioides ES026. Scientific Reports 2017, 7.https://doi.org/10.1038/s41598-017-02834-6
7. Li KF, Cai DB, Wang ZQ, He ZL, Chen SW: Development of an Efficient Genome Editing Tool in Bacillus licheniformis Using CRISPR-Cas9 Nickase. Applied and Environmental Microbiology 2018, 84(6).https://doi.org/10.1128/aem.02608-17
8. Wang ZQ, Haribalan Perumalsamy, Xue Wang and YoungJoon Ahn. "Toxicity and Possible Mechanisms of Action of Honokiol from Magnolia Denudata Seeds against Four Mosquito Species."Scientific Reports9, no. 1 2019: 411.
9. Guangkai Bian1, Jan Rinkel1,Zhangqian Wang1,Lukas Lauterbach, Anwei Hou, Yujie Yuan, Zixin Deng, Tiangang Liu and Jeroen S. Dickschat. "A Clade Ii-D Fungal Chimeric Diterpene Synthase from Colletotrichum Gloeosporioides Produces Dolasta-1(15),8-Diene."Angewandte Chemie International Edition57, no. 48 ,2018: 15887-15890.(影响因子:12.102 一区)
10. Xiangmei Zhang,Zhangqian Wang, Saad Jan, Qian Yang and Mo Wang. "Expression and Functional Analysis of the Lysine Decarboxylase and Copper Amine Oxidase Genes from the Endophytic Fungus Colletotrichum Gloeosporioides Es026." Scientific Reports7, no. 1 (2017): 2766.
11. Zhangqian Wang, Haribalan Perumalsamy, Mo Wang, Shaohua Shu and YoungJoon Ahn. "Larvicidal Activity of Magnolia Denudata Seed Hydrodistillate Constituents and Related Compounds and Liquid Formulations Towards Two Susceptible and Two Wild Mosquito Species."Pest Management Science72, no. 5 (2016): 897-906.(影响因子:3.249一区)
12. XinMei Zhao,Zhangqian Wang,Shao-Hua Shu, WenJuan Wang, HaiJie Xu, YoungJoon Ahn, Mo Wang and Xuebo Hu. "Ethanol and Methanol Can Improve Huperzine a Production from Endophytic Colletotrichum Gloeosporioides Es026."PLOS ONE8, no. 4 (2013): e61777.
13. Zhangqian Wang, Jun Ran Kim, Mo Wang, Shaohua Shu and Young-Joon Ahn. "Larvicidal Activity of Cnidium Monnieri Fruit Coumarins and Structurally Related Compounds against Insecticide-Susceptible and Insecticide-Resistant Culex Pipiens Pallens and Aedes Aegypti."Pest Management Science68, no. 7 (2012): 1041-1047.(影响因子:3.249一区)
14. Zhangqian Wang,HyunKyung Kim., Wenqi Tao, Mo Wang and YoungJoon Ahn. "Contact and Fumigant Toxicity of Cinnamaldehyde and Cinnamic Acid and Related Compounds to Dermatophagoides Farinae and Dermatophagoides Pteronyssinus (Acari: Pyroglyphidae)."Journal of Agricultural and Food Chemistry48, no. 2 (2011): 366-71.(影响因子:3.412一区)
专利
1.一株产bostrycin的蕲艾内生真菌HCH285,发明专利,CN106978356B
2. 一种枯草芽孢杆菌及应用,发明专利,CN114606162A,
3. 一种地衣芽孢杆菌及其应用,发明专利,CN114703088A
4. 副地衣芽孢杆菌及其应用,发明专利,CN114561322A
5. 一种液体培养基以及微生物发酵制备纳米硒的方法,发明专利,CN114958668A