王璋倩 副教授

女，致公党党员，研究生学历，博士，博士后。博士阶段主要从事天然产物研发，微生物资源利用等研究工作，在国际权威SCI期刊， 如Pest Management Science, Scientific Reports等发表学术论文6篇，累计他引56次，单篇他引最高达27次。博士后期间利用基因组挖掘技术发现可合成新颖二萜结构的CgDS环化酶，确证产物的绝对构型、并结合13C同位素标记谱、酶化学等首次揭示了具有独特5/7/6环系Dolastane二萜分子的形成机制。相关研究成果发表在国际权威期刊《德国应用化学》(Angewandte Chemie International Edition, 影响因子12.102)。主持在研国家自然科学基金青年项目1项，完成中国博士后科学基金（一等资助）1项，申请中国发明专利1项。2019年入选湖北省省级人才计划，2020年入选湖北省“三区人才”，对口支援恩施州来凤县。2022年被选派到湖北省随县对口担任中小微企业“科技副总”。

研究领域

天然产物的生物合成（微生物体内生物碱及萜类合成基因的挖掘）

硒在微生物中的吸收转运及代谢工程改造

以生物活性为导向（bioassay guided）的天然产物活性成分研究

教育背景

2016.02-2018.11 博士后 武汉大学药学院 邓子新院士团队 刘天罡教授课题组

2008.09-2015.08 博士 韩国国立首尔大学 农业与生命科学学院 农业生命工学 *导师：Ahn Young Joon 教授（韩国翰林院 院士）

2010.11-2011.03 访学 暨南大 药学院 中药及天然药物研究所 姚新生院士团队

2003.09-2008.03 学士 韩国国立首尔大学 农业与生命科学学院 应用生物化学

发表论文

1.  Wang YD, Yu YH, Duan YH, Wang Q, Cong X, He Y, Gao C, Hafeez M, Jan S, Rasheed SM, Cheng SY, Wang ZQ: Enhancing the Activity of Carboxymethyl Cellulase Enzyme Using Highly Stable Selenium Nanoparticles Biosynthesized by Bacillus paralicheniformis Y4. Molecules 2022, 27(14).https://doi.org/10.3390/molecules27144585

2.  Wang ZQ,Deng JY, U Muhammad, Anwar Naureen, Wang YD,Dong XX, Xu H, He Y,Gao Chao: RHPS4 shifted the conformation ensemble equilibrium of Tel24 by preferentially stabilizing the (3 + 1) hybrid-2 conformation. RSC Advances, 2022, 12, 26011. https://doi.org/10.1039/d2ra03959a

3.  Hafeez M, Ullah F, Khan MM, Wang ZQ, Gul H, Li XW, Huang J, Siddiqui JA, Qasim M, Wang RL, Imran M, Assiri MA, Rehman M, Fahad S, Lu YB: Comparative low lethal effects of three insecticides on demographical traits and enzyme activity of the Spodoptera exigua (Hubner). Environmental Science and Pollution Research 2022, 29(40):60198-60211.https://doi.org/10.1007/s11356-022-20182-5

4.  Siemon T, Wang ZQ, Bian GK, Seitz T, Ye ZL, Lu Y, Cheng S, Ding YK, Huang YL, Deng ZX, Liu TG, Christmann M: Semisynthesis of Plant-Derived Englerin A Enabled by Microbe Engineering of Guaia-6,10(14)-diene as Building Block. Journal of the American Chemical Society 2020, 142(6):2760-27650. https://doi.org/10.1021/jacs.9b12940

5.  Bian GK*, Rinker J*, Wang ZQ*, Lauterbach L, Hou AW, Yuan YJ, Deng ZX, Liu TG, Dickschat JS: A Clade II-D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Produces Dolasta-1(15),8-diene. Angewandte Chemie-International Edition 2018, 57(48):15887-15890.https://doi.org/10.1002/anie.201809954

6.  Zhang XM, Wang ZQ, Jan S, Yang Q, Wang M: Expression and functional analysis of the lysine decarboxylase and copper amine oxidase genes from the endophytic fungus Colletotrichum gloeosporioides ES026. Scientific Reports 2017, 7.https://doi.org/10.1038/s41598-017-02834-6

7.  Li KF, Cai DB, Wang ZQ, He ZL, Chen SW: Development of an Efficient Genome Editing Tool in Bacillus licheniformis Using CRISPR-Cas9 Nickase. Applied and Environmental Microbiology 2018, 84(6).https://doi.org/10.1128/aem.02608-17

8.  Wang ZQ, Haribalan Perumalsamy, Xue Wang and YoungJoon Ahn. "Toxicity and Possible Mechanisms of Action of Honokiol from Magnolia Denudata Seeds against Four Mosquito Species."Scientific Reports9, no. 1 (2019): 411.

9.  Guangkai Bian^┼, Jan Rinkel^┼,Zhangqian Wang^┼,Lukas Lauterbach, Anwei Hou, Yujie Yuan, Zixin Deng, Tiangang Liu and Jeroen S. Dickschat. "A Clade Ii-D Fungal Chimeric Diterpene Synthase from Colletotrichum Gloeosporioides Produces Dolasta-1(15),8-Diene."Angewandte Chemie International Edition57, no. 48 (2018): 15887-15890.（影响因子:12.102一区）

10. Xiangmei Zhang,Zhangqian Wang, Saad Jan, Qian Yang and Mo Wang. "Expression and Functional Analysis of the Lysine Decarboxylase and Copper Amine Oxidase Genes from the Endophytic Fungus Colletotrichum Gloeosporioides Es026." Scientific Reports7, no. 1 (2017): 2766.

11. Zhangqian Wang, Haribalan Perumalsamy, Mo Wang, Shaohua Shu and YoungJoon Ahn. "Larvicidal Activity of Magnolia Denudata Seed Hydrodistillate Constituents and Related Compounds and Liquid Formulations Towards Two Susceptible and Two Wild Mosquito Species."Pest Management Science72, no. 5 (2016): 897-906.（影响因子：3.249一区）

12. XinMei Zhao,Zhangqian Wang,Shao-Hua Shu, WenJuan Wang, HaiJie Xu, YoungJoon Ahn, Mo Wang and Xuebo Hu. "Ethanol and Methanol Can Improve Huperzine a Production from Endophytic Colletotrichum Gloeosporioides Es026."PLOS ONE8, no. 4 (2013): e61777.

13. Zhangqian Wang, Jun Ran Kim, Mo Wang, Shaohua Shu and Young-Joon Ahn. "Larvicidal Activity of Cnidium Monnieri Fruit Coumarins and Structurally Related Compounds against Insecticide-Susceptible and Insecticide-Resistant Culex Pipiens Pallens and Aedes Aegypti."Pest Management Science68, no. 7 (2012): 1041-1047.（影响因子：3.249一区）

14. Zhangqian Wang,HyunKyung Kim., Wenqi Tao, Mo Wang and YoungJoon Ahn. "Contact and Fumigant Toxicity of Cinnamaldehyde and Cinnamic Acid and Related Compounds to Dermatophagoides Farinae and Dermatophagoides Pteronyssinus (Acari: Pyroglyphidae)."Journal of Agricultural and Food Chemistry48, no. 2 (2011): 366-71.（影响因子：3.412一区）

专利

1.一株产bostrycin的蕲艾内生真菌HCH285，发明专利，CN106978356B

2. 一种枯草芽孢杆菌及应用，发明专利，CN114606162A，已公开

3. 一种地衣芽孢杆菌及其应用，发明专利，CN114703088A，已公开

4. 副地衣芽孢杆菌及其应用，发明专利，CN114561322A， 已公开

5. 一种液体培养基以及微生物发酵制备纳米硒的方法，发明专利，CN114958668A，已公开